p38 MAP Kinase Inhibitor X, BIRB 796 - CAS 285983-48-4 - Calbiochem
| Name | p38 MAP Kinase Inhibitor X, BIRB 796 - CAS 285983-48-4 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 506172 |
| Cas Number | 285983-48-4 |
| Formula | C₃₁H₃₇N₅O₃ |
| Purity | ≥99% by HPLC |
| Description | A cell-permeable pyrazolo-napthalenyl urea compound that acts as a highly potent, slowly binding (IC 50 = 8 and 97 nM, respectively, against human p38α, respectively, with or without 2 h preincubation), but high affinity (t 1/2 of dissociation from human p38α = 23 h), p38-selective inhibitor by simultaneously targeting the ATP-binding site and an adjacent DFG-out conformation-specific allosteric cavity |
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