HePTP Inhibitor, ML119 - Calbiochem
| Name | HePTP Inhibitor, ML119 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 375645 |
| Formula | C₂₀H₁₀BrN₃O₄S |
| Purity | ≥98% by HPLC |
| Description | A cell-permeable oxothiazolo-imidazo-pyridinylidene-benzoate that competitively blocks the activity of hematopoietic protein tyrosine phosphatase (HePTP) (IC 50 = 210 nM; K i = 211 nM) and thereby induces sustained hyperactivation of ERK1/2 and p38 MAP kinase (in OKT3-stimulated Jurkat TAg T cells at 4 µM, and in mouse leukocytes (3 mg/kg, i.p.)) without affecting MEK and Akt |
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