ITK Inhibitor, BMS-509744 - CAS 439575-02-7 - Calbiochem

• Supplier: EMD Millipore
• Catalog: 419820
• Cas Number: 439575-02-7
• Formula: C₃₂H₄₁N₅O₄S₂
• Purity: ≥97% by HPLC
• Description: A cell-permeable aminothioaryl-thiazolo compound that potently inhibits ITK kinase activity (IC 50 = 19 nM; [ATP] = 1 µM) in an ATP-competitive manner by stabilizing ITK activation loop in a substrate-blocking, inactive conformation, inhibiting Fyn, IR, Lck, Btk only at much higher concentrations (IC 50 = 1.1, 1.1, 2.4, and 4.1 µM, respectively) and exhibiting little or no activity against 14 other kinases (IC 50 ≥11 µM)

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