JAK2 Inhibitor IX, WP1193
| Name | JAK2 Inhibitor IX, WP1193 |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 420151 |
| Formula | C₁₉H₁₆BrN₃O |
| Purity | ≥95% by HPLC |
| Description | A cell-permeable tyrphostin WP1130 (Cat. No. 681685 ) analog that inhibits JAK2 kinase activity (by >90% at 2.5 µM in in vitro kinase assays) and effectively suppresses JAK2-dependent STAT3 Tyr 705 phosphorylation in murine melanoma B16 and human GSC (glioma stem-like cell) cultures (5 µM), as well as JAK2-dependent Bcr-Abl Tyr 177 phosphorylation in primary human CML PBMCs, Imatinib/STI571-sensitive 32DP210, and IM-resistant Ba/F3-T315I murine leukemia lines (10 µM) |
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