17-AAG
| Name | 17-AAG |
|---|---|
| Supplier | Cell Signaling Technology |
| Catalog | 8132 |
| Prices | $209.00 |
| Sizes | 500 µg |
| Formula | C31H43N3O8 |
| Molecular Weight | 585.70 g/mol |
| Purity | >99% |
| Description | 17-AAG is a semi-synthetic derivative of geldanamycin, demonstrating greater stability than its parent compound (1). It binds specifically to heat shock protein HSP90 in a manner similar to geldanamycin, but with weaker binding (1). Through specific binding with HSP90, 17-AAG has been shown to decrease levels of many proteins including androgen receptor (AR), HER2, and Akt, while increasing levels of HSP90 in prostate cancer cell lines (2). 17-AAG binds to a conserved pocket in the HSP90 family of chaperone proteins and this occupation causes the degradation of several signaling proteins (2). |
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