Erlotinib

Name Erlotinib
Supplier Cell Signaling Technology
Catalog 5083
Prices $89.00
Sizes 10 mg
Formula C22H23N3O4
Molecular Weight 393.44 g/mol
Purity >99%
Description Erlotinib is a novel and potent ATP-competitive inhibitor of the EGFR kinase pathway. It inhibited EGFR autophosphorylation with an IC 50 of 20 nM in vitro and inhibit purified EGFR kinase with an IC 50 of 2 nM (1). Erlotonib is greater than 1000-fold more selective for EGFR than c-src and v-abl (1), ErbB-2, and ErbB-4 (2). Studies have shown that erlotinib inhibits growth and induces G1 cell cycle arrest in multiple cell types, many of which overexpress EGFR (1,3-5).
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