Sorafenib

Name Sorafenib
Supplier Cell Signaling Technology
Catalog 8705
Prices $109.00
Sizes 10 mg
Formula C21H16ClF3N4O3•C7H8O3S
Molecular Weight 637.03 g/mol
Purity >99%
Description Sorafenib, also known as Bay 43-9006, is a novel multikinase inhibitor that targets the RAF family of serine/threonine kinases and tyrosine kinase receptors involved in tumor progression and tumor angiogenesis, including: VEGFR-2 (IC 50 = 90 nM), VEGFR-3 (IC 50 = 20 nM), PDGFR- (IC 50 = 57 nM), c-KIT (IC 50 = 68 nM), and Flt3 (IC 50 = 58 nM) (1). Research studies have demonstrated that sorafenib induces apoptosis in several tumor cell lines through the down-regulation of the antiapoptotic protein myeloid cell leukemia-1 (Mcl-1). Down-regulation of Mcl-1 by sorafenib is associated with the release of cytochrome c from mitochondria into the cytosol and caspase activation, leading to apoptotic cell death (2). STAT3 inhibition by sorafenib has been observed in multiple cell types (3-5).
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