SP600125
| Name | SP600125 |
|---|---|
| Supplier | Cell Signaling Technology |
| Catalog | 8177 |
| Prices | $199.00 |
| Sizes | 10 mg |
| Formula | C14H8N2O |
| Molecular Weight | 220.23 g/mol |
| Purity | >99% |
| Description | Novel, potent, and selective JNK-1,-2, and -3 inhibitor, SP600125 is an ATP-competetive inhibitor effective on a range of kinases and enzymes. In cells, SP600125 caused a dose-dependent inhibition of the phosphorylation of c-Jun, the expression of inflammatory genes IL-2, COX-2, TNF-α, IFN-γ, and blocked the activation and differentiation of primary human CD4 cell cultures (1). SP600125 has also demonstrated inhibitory effects on tumor cell proliferation, endothelial cell migration, and tumor growth as well as blocking tumor and endothelial cells in the G 2 phase of the cell cycle (2). |
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Product images
Western blot analysis of extracts from 293T cells, untreated or treated with anisomycin (25 μg/ml) for the indicated times either with or without SP600125 pre-treatment (50 μM, 40 min), using Phospho-JunB (Thr102/Thr104) (D3C6) Rabbit mAb #8053 (upper) or JunB (C37F9) Rabbit mAb #3753 (lower).
Western blot analysis of extracts from 293T cells, untreated or treated with anisomycin (25 μg/ml, 15 min) either with or without SP600125 pre-treatment (50 μM, 40 min), using Phospho-c-Jun (Ser73) (D47G9) XP ® Rabbit mAb #3270 (upper) or c-Jun (60A8) Rabbit mAb #9165 (lower).
Chemical structure of SP600125.