TPA (12-O-Tetradecanoylphorbol-13-Acetate)

Name TPA (12-O-Tetradecanoylphorbol-13-Acetate)
Supplier Cell Signaling Technology
Catalog 4174
Prices $79.00
Sizes 1 mg
Formula C36H56O8
Molecular Weight 616.84 g/mol
Purity >99.5%
Description TPA (12-O-tetradecanoylphorbol-13-acetate) / PMA (phorbol-12-myristate-13-acetate) is the most commonly used phorbol ester. It binds and activates protein kinase C, causing a wide range of effects in cells and tissues (1,2). TPA has been demonstrated to be a potent tumor promoter in mouse skin (3). Conversely, it has been shown to be an effective cancer therapeutic agent in myelocytic leukemia patients, and has been indicated as a potential colorectal cancer therapeutic (4-5). TPA has also been shown to increase white blood cell and neutrophil counts in solid tumor cancer patients (6).
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