Vinblastine

Name Vinblastine
Supplier Cell Signaling Technology
Catalog 14255
Prices $69.00
Sizes 5 mg
Formula C46H58N4O9•H2SO4
Molecular Weight 909.05 g/mol
Purity >98%
Description Vinblastine is a vinca alkaloid derived from the plant Catharanthus roseus . Like other vinca alkaloids, it acts as a mitotic inhibitor blocking microtubule assembly in vitro (1,2). Investigators have demonstrated that vinblastine binds to and inhibits the addition of tubulin dimers to the assembly end of steady-state microtubules in a dose-dependent manner (K i = ~178 nM) (1). This disruption of mitotic spindle causes mitotic arrest, inhibits cell proliferation, and induces apoptosis (1-3). Studies have suggested that high concentrations of vinblastine depolymerize microtubules, but this is not required for inhibition of cell proliferation (2). Treatment of cells with vinblastine has been shown to activate the SAPK/JNK pathway, leading to expression and phosphorylation of c-Jun (3,4) and phosphorylation of the anti-apoptotic proteins Bcl-2 and Bcl-xL (5,6).
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