Y-27632
| Name | Y-27632 |
|---|---|
| Supplier | Cell Signaling Technology |
| Catalog | 13624 |
| Prices | $99.00 |
| Sizes | 1 mg |
| Formula | C14H21N3O·2HCl |
| Molecular Weight | 320.30 g/mol |
| Purity | >98% |
| Description | Y-27632 is a potent and selective ATP-competitive inhibitor of Rho-associated kinases (ROCK), with K i values of 0.22 µM and 0.30 µM for ROCK1 and ROCK2, respectively. In vitro kinase assays demonstrate that Y-27632 exhibits a 20-fold greater preference for ROCK when compared to citron kinase and protein kinase N (1). Research studies show that Y-27632 treatment of cells leads to inhibition of ROCK phosphorylation of myosin phosphatase subunit 1 (MYPT1) at both Thr853 and Thr696, with a much greater inhibition of Thr853 phosphorylation (2,3). Y-27632 selectively inhibits smooth-muscle contraction by inhibiting Ca 2+ sensitization (4). Additional research indicates that Y-27632 inhibits dissociation-induced apoptosis of cultured human embryonic stem cells over numerous passages and increases cloning efficiency (5). |
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