Torin 1

• Supplier: R&D Systems
• Catalog: 4247
• Prices: $249.00, $1,025.00
• Sizes: 10 mg, 50 mg
• Cas Number: 1222998-36-8
• Chemical Name: 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
• Formula: C35H28F3N5O2
• Molecular Weight: 607.62
• Purity: >98%

Product References

Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and - Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and

Kimura T, Nada S, Takegahara N, Okuno T, Nojima S, Kang S, Ito D, Morimoto K, Hosokawa T, Hayama Y, Mitsui Y, Sakurai N, Sarashina-Kida H, Nishide M, Maeda Y, Takamatsu H, Okuzaki D, Yamada M, Okada M, Kumanogoh A. Nat Commun. 2016 Oct 12;7:13130.

mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation - mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation

Pema M, Drusian L, Chiaravalli M, Castelli M, Yao Q, Ricciardi S, Somlo S, Qian F, Biffo S, Boletta A. Nat Commun. 2016 Mar 2;7:10786.

Trehalose, sucrose and raffinose are novel activators of autophagy in human - Trehalose, sucrose and raffinose are novel activators of autophagy in human

Chen X, Li M, Li L, Xu S, Huang D, Ju M, Huang J, Chen K, Gu H. Sci Rep. 2016 Jun 22;6:28423.

An evolutionarily conserved mechanism for cAMP elicited axonal regeneration - An evolutionarily conserved mechanism for cAMP elicited axonal regeneration

Hao Y, Frey E, Yoon C, Wong H, Nestorovski D, Holzman LB, Giger RJ, DiAntonio A, Collins C. Elife. 2016 Jun 7;5. pii: e14048.

mTOR controls lysosome tubulation and antigen presentation in macrophages and - mTOR controls lysosome tubulation and antigen presentation in macrophages and

Saric A, Hipolito VE, Kay JG, Canton J, Antonescu CN, Botelho RJ. Mol Biol Cell. 2016 Jan 15;27(2):321-33.

A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy - A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy

Zhang J, Lachance V, Schaffner A, Li X, Fedick A, Kaye LE, Liao J, Rosenfeld J, Yachelevich N, Chu ML, Mitchell WG, Boles RG, Moran E, Tokita M, Gorman E, Bagley K, Zhang W, Xia F, Leduc M, Yang Y, Eng C, Wong LJ, Schiffmann R, Diaz GA, Kornreich R, Thummel R, Wasserstein M, Yue Z, Edelmann L. PLoS Genet. 2016 Apr 27;12(4):e1005848.

The Loss of Lam2 and Npr2-Npr3 Diminishes the Vacuolar Localization of Gtr1-Gtr2 - The Loss of Lam2 and Npr2-Npr3 Diminishes the Vacuolar Localization of Gtr1-Gtr2

Ma N, Ma Y, Nakashima A, Kikkawa U, Furuyashiki T. PLoS One. 2016 May 26;11(5):e0156239.

Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 - Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42

Speranza L, Giuliano T, Volpicelli F, De Stefano ME, Lombardi L, Chambery A, Lacivita E, Leopoldo M, Bellenchi GC, di Porzio U, Crispino M, Perrone-Capano C. Front Behav Neurosci. 2015 Mar 11;9:62.

The MAPK and PI3K pathways mediate CNTF-induced neuronal survival and process - The MAPK and PI3K pathways mediate CNTF-induced neuronal survival and process

Askvig JM, Watt JA. J Cell Commun Signal. 2015 Sep;9(3):217-31.

The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine - The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine

Chung J, Bauer DE, Ghamari A, Nizzi CP, Deck KM, Kingsley PD, Yien YY, Huston NC, Chen C, Schultz IJ, Dalton AJ, Wittig JG, Palis J, Orkin SH, Lodish HF, Eisenstein RS, Cantor AB, Paw BH. Sci Signal. 2015 Apr 14;8(372):ra34.