Echinomycin

Name Echinomycin
Supplier R&D Systems
Catalog 5520
Prices $105.00
Sizes 1 mg
Cas Number 512-64-1
Chemical Name N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-L-valine-(81)-lactone-cyclic(37)-thioether
Formula C51H64N12O12S2
Molecular Weight 1101.26
Purity >98%
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Product References

Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding - Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding

Kong D, Park EJ, Stephen AG, Calvani M, Cardellina JH, Monks A, Fisher RJ, Shoemaker RH, Melillo G. Cancer Res. 2005 Oct 1;65(19):9047-55.

Targeting HIF1alpha eliminates cancer stem cells in hematological malignancies. - Targeting HIF1alpha eliminates cancer stem cells in hematological malignancies.

Wang Y, Liu Y, Malek SN, Zheng P, Liu Y. Cell Stem Cell. 2011 Apr 8;8(4):399-411.

Physical and functional interactions between Runx2 and HIF-1alpha induce vascular - Physical and functional interactions between Runx2 and HIF-1alpha induce vascular

Kwon TG, Zhao X, Yang Q, Li Y, Ge C, Zhao G, Franceschi RT. J Cell Biochem. 2011 Dec;112(12):3582-93.