AZ 628

• Supplier: R&D Systems
• Catalog: 4836
• Prices: $219.00, $905.00
• Sizes: 10 mg, 50 mg
• Cas Number: 878739-06-1
• Chemical Name: 3-(1-Cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]benzamide
• Formula: C27H25N5O2
• Molecular Weight: 451.52
• Purity: >98%

Product References

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance - RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance

Hatzivassiliou G, Song K, Yen I, Brandhuber BJ, Anderson DJ, Alvarado R, Ludlam MJ, Stokoe D, Gloor SL, Vigers G, Morales T, Aliagas I, Liu B, Sideris S, Hoeflich KP, Jaiswal BS, Seshagiri S, Koeppen H, Belvin M, Friedman LS, Malek S. Nature. 2010 Mar 18;464(7287):431-5.

Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition - Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition

Montagut C, Sharma SV, Shioda T, McDermott U, Ulman M, Ulkus LE, Dias-Santagata D, Stubbs H, Lee DY, Singh A, Drew L, Haber DA, Settleman J. Cancer Res. 2008 Jun 15;68(12):4853-61.

Selective Raf inhibition in cancer therapy. - Selective Raf inhibition in cancer therapy.

Khazak V, Astsaturov I, Serebriiskii IG, Golemis EA. Expert Opin Ther Targets. 2007 Dec;11(12):1587-609.