AP 24534

• Supplier: R&D Systems
• Catalog: 4274
• Prices: $245.00, $1,005.00
• Sizes: 10 mg, 50 mg
• Cas Number: 943319-70-8
• Chemical Name: 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide
• Formula: C29H27F3N6O
• Molecular Weight: 532.56
• Purity: >98%

Product References

Discovery of - Discovery of

Huang WS, Metcalf CA, Sundaramoorthi R, Wang Y, Zou D, Thomas RM, Zhu X, Cai L, Wen D, Liu S, Romero J, Qi J, Chen I, Banda G, Lentini SP, Das S, Xu Q, Keats J, Wang F, Wardwell S, Ning Y, Snodgrass JT, Broudy MI, Russian K, Zhou T, Commodore L, Narasimhan NI, Mohemmad QK, Iuliucci J, Rivera VM, Dalgarno DC, Sawyer TK, Clackson T, Shakespeare WC. J Med Chem. 2010 Jun 24;53(12):4701-19.

Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid - Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid

Gozgit JM, Wong MJ, Wardwell S, Tyner JW, Loriaux MM, Mohemmad QK, Narasimhan NI, Shakespeare WC, Wang F, Druker BJ, Clackson T, Rivera VM. Mol Cancer Ther. 2011 Jun;10(6):1028-35.

AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits - AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits

O'Hare T, Shakespeare WC, Zhu X, Eide CA, Rivera VM, Wang F, Adrian LT, Zhou T, Huang WS, Xu Q, Metcalf CA 3rd, Tyner JW, Loriaux MM, Corbin AS, Wardwell S, Ning Y, Keats JA, Wang Y, Sundaramoorthi R, Thomas M, Zhou D, Snodgrass J, Commodore L, Sawyer TK, Dalgarno DC, Deininger MW, Druker BJ, Clackson T. Cancer Cell. 2009 Nov 6;16(5):401-12.