Torin 2

Name Torin 2
Supplier R&D Systems
Catalog 4248
Prices $225.00, $925.00
Sizes 10 mg, 50 mg
Cas Number 1223001-51-1
Chemical Name 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one
Formula C24H15F3N4O
Molecular Weight 432.4
Purity >98%
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Product References

PI3K/mTORC2 regulates TGF-beta/Activin signalling by modulating Smad2/3 activity - PI3K/mTORC2 regulates TGF-beta/Activin signalling by modulating Smad2/3 activity

Yu JS, Ramasamy TS, Murphy N, Holt MK, Czapiewski R, Wei SK, Cui W. Nat Commun. 2015 May 22;6:7212.

Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in - Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in

Toops KA, Tan LX, Jiang Z, Radu RA, Lakkaraju A. Mol Biol Cell. 2015 Jan 1;26(1):1-14.

Dual Targeting of mTOR Activity with Torin2 Potentiates Anticancer Effects of - Dual Targeting of mTOR Activity with Torin2 Potentiates Anticancer Effects of

Hussain AR, Al-Romaizan M, Ahmed M, Thangavel S, Al-Dayel F, Beg S, Uddin S, Siraj AK, Al-Kuraya KS. Mol Med. 2015 May 26;21:466-78.

Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling - Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling

Brown MC, Dobrikov MI, Gromeier M. J Virol. 2014 Nov;88(22):13149-60.

High prevalence of mTOR complex activity can be targeted using Torin2 in - High prevalence of mTOR complex activity can be targeted using Torin2 in

Ahmed M, Hussain AR, Bavi P, Ahmed SO, Al Sobhi SS, Al-Dayel F, Uddin S, Al-Kuraya KS. Carcinogenesis. 2014 Jul;35(7):1564-72.

Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled - Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled

Zullo AJ, Jurcic Smith KL, Lee S. BMC Biochem. 2014 Feb 14;15:4.

Parallel measurement of dynamic changes in translation rates in single cells. - Parallel measurement of dynamic changes in translation rates in single cells.

Han K, Jaimovich A, Dey G, Ruggero D, Meyuhas O, Sonenberg N, Meyer T. Nat Methods. 2014 Jan;11(1):86-93.

ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early - ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early

Montane MH, Menand B. J Exp Bot. 2013 Nov;64(14):4361-74.

Protein phosphatase 2A isoforms utilizing Abeta scaffolds regulate - Protein phosphatase 2A isoforms utilizing Abeta scaffolds regulate

Hwang JH, Jiang T, Kulkarni S, Faure N, Schaffhausen BS. J Biol Chem. 2013 Nov 1;288(44):32064-73.