GDC 0879

• Supplier: R&D Systems
• Catalog: 4453
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Cas Number: 905281-76-7
• Chemical Name: (E)-2,3-Dihydro-5-[1-(2-hydroxyethyl)-3-(4-pyridinyl)-1H-pyrazol-4-yl]-1H-inden-1-oneoxime
• Formula: C19H18N4O2
• Molecular Weight: 334.37
• Purity: >98%

Product References

Pharmacodynamics of - Pharmacodynamics of

Wong H, Belvin M, Herter S, Hoeflich KP, Murray LJ, Wong L, Choo EF. J Pharmacol Exp Ther. 2009 Apr;329(1):360-7.

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance - RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance

Hatzivassiliou G, Song K, Yen I, Brandhuber BJ, Anderson DJ, Alvarado R, Ludlam MJ, Stokoe D, Gloor SL, Vigers G, Morales T, Aliagas I, Liu B, Sideris S, Hoeflich KP, Jaiswal BS, Seshagiri S, Koeppen H, Belvin M, Friedman LS, Malek S. Nature. 2010 Mar 18;464(7287):431-5.

Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E - Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E

Hoeflich KP, Herter S, Tien J, Wong L, Berry L, Chan J, O'Brien C, Modrusan Z, Seshagiri S, Lackner M, Stern H, Choo E, Murray L, Friedman LS, Belvin M. Cancer Res. 2009 Apr 1;69(7):3042-51.