A 1070722

• Supplier: Tocris Bioscience
• Catalog: Cat.No.
• Prices: $185.00, $755.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1384424-80-9
• Chemical Name: 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
• Formula: C17H13F3N4O2
• Molecular Weight: 362.31
• Purity: >99 %
• Description: Potent glycogen synthase kinase-3 (GSK-3) inhibitor (K i = 0.6 nM for GSK-3 α and GSK-3 β ). Displays high selectivity (> 50-fold) for GSK-3 over a panel of other kinases tested, including CDK family members. Decreases phosphorylation of microtubule-associated protein Tau in vitro ; protects rat primary cortical neurons against β amyloid and glutamate challenge. Brain penetrant.