A 205804

• Supplier: Tocris Bioscience
• Catalog: 3793
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 251992-66-2
• Chemical Name: 4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide
• Formula: C15H12N2OS2
• Molecular Weight: 300.39
• Purity: >98 %
• Description: Selective inhibitor of E-selectin and ICAM-1 expression (IC 50 values are 20, 25 and > 1000 nM for TNF- α -induced E-selectin, ICAM-1 and VCAM-1 expression respectively). Effective inhibitor of cell-cell adhesion in an in vitro flow experiment.

Product References

Discovery of inhibitors of cell adhesion molecule expression in human endothelial - Discovery of inhibitors of cell adhesion molecule expression in human endothelial

Stewart AO, Bhatia PA, McCarty CM, Patel MV, Staeger MA, Arendsen DL, Gunawardana IW, Melcher LM, Zhu GD, Boyd SA, Fry DG, Cool BL, Kifle L, Lartey K, Marsh KC, Kempf-Grote AJ, Kilgannon P, Wisdom W, Meyer J, Gallatin WM, Okasinski GF. J Med Chem. 2001 Mar 15;44(6):988-1002.

Selective inhibition of ICAM-1 and E-selectin expression in human endothelial - Selective inhibition of ICAM-1 and E-selectin expression in human endothelial

Zhu GD, Arendsen DL, Gunawardana IW, Boyd SA, Stewart AO, Fry DG, Cool BL, Kifle L, Schaefer V, Meuth J, Marsh KC, Kempf-Grote AJ, Kilgannon P, Gallatin WM, Okasinski GF. J Med Chem. 2001 Oct 11;44(21):3469-87.

Synthesis and mode of action of (125)I- and (3)H-labeled thieno[2,3-c]pyridine - Synthesis and mode of action of (125)I- and (3)H-labeled thieno[2,3-c]pyridine

Zhu GD, Schaefer V, Boyd SA, Okasinski GF. J Org Chem. 2002 Feb 8;67(3):943-8.