| Name | A 331440 dihydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4228 |
| Prices | $199.00, $825.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 1049740-32-0 |
| Chemical Name | 4'-[3-[(3R)-3-(Dimethylamino)-1-pyrrolidinyl]propoxy]-[1,1'-biphenyl]-4-carbonitriledihydrochloride |
| Formula | C22H27N3O.2HCl |
| Molecular Weight | 422.39 |
| Purity | >98 % |
| Description | High affinity histamine H 3 receptor antagonist (K i values are 21.7 and 22.7 nM for rat and human H 3 receptors, respectively). Exhibits selectivity for human H 3 over H 1 , H 2 and H 4 receptors (K i values are 2940, 14400 and >10000 nM respectively). Shown to reduce weight in a diet-induced obesity model. |
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Hancock AA, Bennani YL, Bush EN, Esbenshade TA, Faghih R, Fox GB, Jacobson P, Knourek-Segel V, Krueger KM, Nuss ME, Pan JB, Shapiro R, Witte DG, Yao BB. Eur J Pharmacol. 2004 Mar 8;487(1-3):183-97.
Hancock AA, Diehl MS, Faghih R, Bush EN, Krueger KM, Krishna G, Miller TR, Wilcox DM, Nguyen P, Pratt JK, Cowart MD, Esbenshade TA, Jacobson PB. Basic Clin Pharmacol Toxicol. 2004 Sep;95(3):144-52.