A 350619 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4697
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Activator
• Cas Number: 1217201-17-6
• Chemical Name: 3-[2-[(4-Chlorophenyl)thiophenyl]-N-[4-(dimethylamino)butyl]-2-propenamidehydrochloride
• Formula: C21H25ClN2OS.HCl
• Molecular Weight: 425.41
• Purity: >99 %
• Description: Activator of soluble guanylyl cyclase (sGC). Activates basal sGC and synergistically activates sGC in the presence of NO. Relaxes cavernosum smooth muscle in vitro and induces penile erections in rats. Induces a sustained increase in skin blood flow in vivo .

Product References

A-350619: a novel activator of soluble guanylyl cyclase. - A-350619: a novel activator of soluble guanylyl cyclase.

Miller LN, Nakane M, Hsieh GC, Chang R, Kolasa T, Moreland RB, Brioni JD. Life Sci. 2003 Jan 17;72(9):1015-25.

NO-independent stimulators and activators of soluble guanylate cyclase: discovery - NO-independent stimulators and activators of soluble guanylate cyclase: discovery

Evgenov OV, Pacher P, Schmidt PM, Hasko G, Schmidt HH, Stasch JP. Nat Rev Drug Discov. 2006 Sep;5(9):755-68.

Anodal iontophoresis of a soluble guanylate cyclase stimulator induces a - Anodal iontophoresis of a soluble guanylate cyclase stimulator induces a

Kotzki S, Roustit M, Arnaud C, Boutonnat J, Blaise S, Godin-Ribuot D, Cracowski JL. J Pharmacol Exp Ther. 2013 Sep;346(3):424-31.