A 412997 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 5163
• Prices: $139.00, $565.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 1347744-96-0
• Chemical Name: N-(3-Methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide
• Formula: C19H23N3O.2HCl
• Molecular Weight: 382.33
• Purity: >98 %
• Description: Selective agonist for the dopamine D 4 receptor (K i values are 7.9 and 12.1 nM for human D 4 and rat D 4 receptors). Displays no affinity (<1000 nM) for other dopamine receptors. Shows efficacy in rat models of ADHD and short-term memory.

Product References

A-412997, a selective dopamine D4 agonist, improves cognitive performance in - A-412997, a selective dopamine D4 agonist, improves cognitive performance in

Browman KE, Curzon P, Pan JB, Molesky AL, Komater VA, Decker MW, Brioni JD, Moreland RB, Fox GB. Pharmacol Biochem Behav. 2005 Sep;82(1):148-55. Epub 2005 Sep 8.

A-412997 is a selective dopamine D4 receptor agonist in rats. - A-412997 is a selective dopamine D4 receptor agonist in rats.

Moreland RB, Patel M, Hsieh GC, Wetter JM, Marsh K, Brioni JD. Pharmacol Biochem Behav. 2005 Sep;82(1):140-7. Epub 2005 Sep 8.

Discovery of - Discovery of

Patel MV, Kolasa T, Mortell K, Matulenko MA, Hakeem AA, Rohde JJ, Nelson SL, Cowart MD, Nakane M, Miller LN, Uchic ME, Terranova MA, El-Kouhen OF, Donnelly-Roberts DL, Namovic MT, Hollingsworth PR, Chang R, Martino BR, Wetter JM, Marsh KC, Martin R, Darbyshire JF, Gintant G, Hsieh GC, Moreland RB, Sullivan JP, Brioni JD, Stewart AO. J Med Chem. 2006 Dec 14;49(25):7450-65.