A 419259 trihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4552
• Prices: $279.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 1435934-25-0
• Chemical Name: 7-[trans-4-(4-Methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-Pyrrolo[2,3-d]pyrimidin-4-aminetrihydrochloride
• Formula: C29H34N6O.3HCl
• Molecular Weight: 592.01
• Purity: >98 %
• Description: Potent Hck inhibitor (IC 50 = 0.43 nM). Also inhibits other Src family kinases (SFKs). Suppresses proliferation and induces apoptosis in CML cell lines including CD34 + . Also inhibits acute myeloid leukemia (AML) stem cell proliferation in vitro and in vivo .

Product References

Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family - Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family

Wilson MB, Schreiner SJ, Choi HJ, Kamens J, Smithgall TE. Oncogene. 2002 Nov 21;21(53):8075-88.

An inhibitor-resistant mutant of Hck protects CML cells against the - An inhibitor-resistant mutant of Hck protects CML cells against the

Pene-Dumitrescu T, Peterson LF, Donato NJ, Smithgall TE. Oncogene. 2008 Nov 27;27(56):7055-69.

A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo. - A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo.

Saito Y, Yuki H, Kuratani M, Hashizume Y, Takagi S, Honma T, Tanaka A, Shirouzu M, Mikuni J, Handa N, Ogahara I, Sone A, Najima Y, Tomabechi Y, Wakiyama M, Uchida N, Tomizawa-Murasawa M, Kaneko A, Tanaka S, Suzuki N, Kajita H, Aoki Y, Ohara O, Shultz LD, Fukami T, Goto T, Taniguchi S, Yokoyama S, Ishikawa F. Sci Transl Med. 2013 Apr 17;5(181):181ra52.