A 61603 hydrobromide

• Supplier: Tocris Bioscience
• Catalog: 4341
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 107756-30-9
• Chemical Name: N-[5-(4,5-Dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamidehydrobromide
• Formula: C14H19N3O3S.HBr
• Molecular Weight: 390.29
• Description: Potent α -adrenoceptor agonist that is at least 35-fold more potent at α 1A than at α 1B or α 1D sites. Induces dose response increases in spontaneous Ca 2+ transients in rat ventricular myocytes in vitro (EC 50 = 6.9 nmol/L). Also available as part of the α 1 -Adrenoceptor Tocriset™ .

Product References

A-61603, a potent alpha 1-adrenergic receptor agonist, selective for the alpha 1A - A-61603, a potent alpha 1-adrenergic receptor agonist, selective for the alpha 1A

Knepper SM, Buckner SA, Brune ME, DeBernardis JF, Meyer MD, Hancock AA. J Pharmacol Exp Ther. 1995 Jul;274(1):97-103.

Synthesis and in vitro characterization of - Synthesis and in vitro characterization of

Meyer MD, Altenbach RJ, Hancock AA, Buckner SA, Knepper SM, Kerwin JF Jr. J Med Chem. 1996 Sep 27;39(20):4116-9.

Receptor subtype involved in alpha 1-adrenergic receptor-mediated Ca2+ signaling - Receptor subtype involved in alpha 1-adrenergic receptor-mediated Ca2+ signaling

Luo DL, Gao J, Fan LL, Tang Y, Zhang YY, Han QD. Acta Pharmacol Sin. 2007 Jul;28(7):968-74.