A 740003

• Supplier: Tocris Bioscience
• Catalog: 1534
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 861393-28-4
• Chemical Name: N-[1-[[(Cyanoamino)(5-quinolinylamino)methylene]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide
• Formula: C26H30N6O3
• Molecular Weight: 474.55
• Purity: >98 %
• Description: Potent and selective P2X 7 receptor antagonist (IC 50 values are 18 and 40 nM for rat and human receptors respectively). Displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 μ M. Reduces nociception in animal models of persistent neuropathic and inflammatory pain. Also reduces neuroblastoma tumor growth in mice.

Product References

A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) - A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino)

Honore P, Donnelly-Roberts D, Namovic MT, Hsieh G, Zhu CZ, Mikusa JP, Hernandez G, Zhong C, Gauvin DM, Chandran P, Harris R, Medrano AP, Carroll W, Marsh K, Sullivan JP, Faltynek CR, Jarvis MF. J Pharmacol Exp Ther. 2006 Dec;319(3):1376-85. Epub 2006 Sep 18.

Novel P2X7 receptor antagonists ease the pain. - Novel P2X7 receptor antagonists ease the pain.

King BF. Br J Pharmacol. 2007 Jul;151(5):565-7. Epub 2007 Apr 30.

Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and - Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and

Donnelly-Roberts DL, Namovic MT, Han P, Jarvis MF. Br J Pharmacol. 2009 Aug;157(7):1203-14.

The P2X7 receptor is a key modulator of the PI3K/GSK3beta/VEGF signaling network: - The P2X7 receptor is a key modulator of the PI3K/GSK3beta/VEGF signaling network:

Amoroso F, Capece M, Rotondo A, Cangelosi D, Ferracin M, Franceschini A, Raffaghello L, Pistoia V, Varesio L, Adinolfi E. Oncogene. 2015 Jan 26.