A 803467

• Supplier: Tocris Bioscience
• Catalog: 4319
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Blocker
• Cas Number: 944261-79-4
• Chemical Name: 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide
• Formula: C19H16ClNO4
• Molecular Weight: 357.79
• Purity: >98 %
• Description: Selective blocker of Na V 1.8 channels (IC 50 values are 8, 2450, 6740, 7340 and 7380 nM for hNa V 1.8, hNa V 1.3, hNa V 1.7, hNa V 1.5 and hNa V 1.2 channels respectively). Shows no significant activity against TRPV1, P2X 2/3 , Ca V 2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.

Product References

Painful research: identification of a small-molecule inhibitor that selectively - Painful research: identification of a small-molecule inhibitor that selectively

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Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and - Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and

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A selective Nav1.8 sodium channel blocker, A-803467 - A selective Nav1.8 sodium channel blocker, A-803467

McGaraughty S, Chu KL, Scanio MJ, Kort ME, Faltynek CR, Jarvis MF. J Pharmacol Exp Ther. 2008 Mar;324(3):1204-11. Epub 2007 Dec 18.