A 839977

• Supplier: Tocris Bioscience
• Catalog: 2939
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 870061-27-1
• Chemical Name: 1-(2,3-Dichlorophenyl)-N-[[2-(2-pyridinyloxy)phenyl]methyl]-1H-tetrazol-5-amine
• Formula: C19H14Cl2N6O
• Molecular Weight: 413.26
• Purity: >98 %
• Description: Potent P2X 7 antagonist; blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X 7 receptors (IC 50 values are 20, 42 and 150 nM respectively). Displays antinociceptive effects in rat and mice models of inflammatory pain. CNS penetrant.

Product References

The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, - The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977,

Honore P, Donnelly-Roberts D, Namovic M, Zhong C, Wade C, Chandran P, Zhu C, Carroll W, Perez-Medrano A, Iwakura Y, Jarvis MF. Behav Brain Res. 2009 Dec 1;204(1):77-81.

Recent patents on novel P2X(7) receptor antagonists and their potential for - Recent patents on novel P2X(7) receptor antagonists and their potential for

Friedle SA, Curet MA, Watters JJ. Recent Pat CNS Drug Discov. 2010 Jan;5(1):35-45.