A 844606

• Supplier: Tocris Bioscience
• Catalog: 4232
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 861119-08-6
• Chemical Name: 2-(Hexahydro-5-methylpyrrolo[3,4-c]pyrrol-2(1H)-yl)-9H-xanthen-9-one
• Formula: C20H20N2O2
• Molecular Weight: 320.38
• Purity: >99 %
• Description: Selective α 7 nicotinic acetylcholine receptor (nAChR) partial agonist (EC 50 values are 1.4 and 2.2 μ M at human and rat receptors respectively). Displays no measurable effect on α 4 β 2 nAChRs. Stimulates α 7 nAChR-induced ERK1/2 phosphorylation in PC12 cells.

Product References

Structure-activity relationship of triazafluorenone derivatives as potent and - Structure-activity relationship of triazafluorenone derivatives as potent and

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More L, Gravius A, Pietraszek M, Belozertseva I, Malyshkin A, Shekunova E, Barberi C, Schaefer D, Schmidt WJ, Danysz W. Behav Pharmacol. 2007 Jul;18(4):273-81.