A 85380 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4477
• Prices: $195.00
• Sizes: 10 mg
• Function Type: Agonist
• Cas Number: 174740-86-4
• Chemical Name: 3-[(2S)-2-Azetidinylmethoxy]-pyridinedihydrochloride
• Formula: C9H12N2O.2HCl
• Molecular Weight: 237.13
• Purity: >98 %
• Description: High affinity and selective α 4 β 2 nACh receptor agonist (K i values are 0.05, 148 and 314 nM for α 4 β 2, α 7 and α 1 β 1 δ γ receptors respectively). Stimulates cation efflux in K177 cells expressing α 4 β 2.

Product References

Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic - Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic

Abreo MA, Lin NH, Garvey DS, Gunn DE, Hettinger AM, Wasicak JT, Pavlik PA, Martin YC, Donnelly-roberts DL, Anderson DJ, Sullivan JP, Williams M, Arneric SP, Holladay MW. J Med Chem. 1996 Feb 16;39(4):817-25.

A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological - A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological

Sullivan JP, Donnelly-Roberts D, Briggs CA, Anderson DJ, Gopalakrishnan M, Piattoni-Kaplan M, Campbell JE, McKenna DG, Molinari E, Hettinger AM, Garvey DS, Wasicak JT, Holladay MW, Williams M, Arneric SP. Neuropharmacology. 1996 Jun;35(6):725-34.