A 867744

• Supplier: Tocris Bioscience
• Catalog: 5017
• Prices: $185.00, $755.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 1000279-69-5
• Chemical Name: 4-[5-(4-Chlorophenyl)-2-methyl-3-(1-oxopropyl)-1H-pyrrol-1-yl]benzenesulfonamide
• Formula: C20H19ClN2O3S
• Molecular Weight: 402.89
• Purity: >97 %
• Description: Positive allosteric modulator of α 7 nAChRs (IC 50 values are 0.98 and 1.12 μ M for human and rat α 7 receptor ACh-evoked currents respectively, in X. laevis oocytes). Displays no activity at 5-HT 3A , α 3 β 4 or α 4 β 2 nAChRs. Brain penetrant.

Product References

Discovery of - Discovery of

Faghih R, Gopalakrishnan SM, Gronlien JH, Malysz J, Briggs CA, Wetterstrand C, Ween H, Curtis MP, Sarris KA, Gfesser GA, El-Kouhen R, Robb HM, Radek RJ, Marsh KC, Bunnelle WH, Gopalakrishnan M. J Med Chem. 2009 May 28;52(10):3377-84.

In vitro pharmacological characterization of a novel allosteric modulator of - In vitro pharmacological characterization of a novel allosteric modulator of

Malysz J, Gronlien JH, Anderson DJ, Hakerud M, Thorin-Hagene K, Ween H, Wetterstrand C, Briggs CA, Faghih R, Bunnelle WH, Gopalakrishnan M. J Pharmacol Exp Ther. 2009 Jul;330(1):257-67.