A 922500

• Supplier: Tocris Bioscience
• Catalog: 4249
• Prices: $309.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 959122-11-3
• Chemical Name: (1R,2R)-2-[[4'-[[Phenylamino)carbonyl]amino][1,1'-biphenyl]-4-yl]carbonyl]cyclopentanecarboxylicacid
• Formula: C26H24N2O4
• Molecular Weight: 428.48
• Purity: >98 %
• Description: Diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC 50 values are 7 and 24 nM at human and mouse DGAT-1 respectively) that is devoid of activity at DGAT-2, ACAT1 or ACAT2. Induces significant weight loss without altering food intake, and decreases liver and plasma triglyceride levels in vivo . Orally active.

Product References

Validation of diacyl glycerolacyltransferase I as a novel target for the - Validation of diacyl glycerolacyltransferase I as a novel target for the

Zhao G, Souers AJ, Voorbach M, Falls HD, Droz B, Brodjian S, Lau YY, Iyengar RR, Gao J, Judd AS, Wagaw SH, Ravn MM, Engstrom KM, Lynch JK, Mulhern MM, Freeman J, Dayton BD, Wang X, Grihalde N, Fry D, Beno DW, Marsh KC, Su Z, Diaz GJ, Collins CA, Sham H, Reilly RM, Brune ME, Kym PR. J Med Chem. 2008 Feb 14;51(3):380-3.

Diacylglycerol acyltransferase 1 inhibition lowers serum triglycerides in the - Diacylglycerol acyltransferase 1 inhibition lowers serum triglycerides in the

King AJ, Segreti JA, Larson KJ, Souers AJ, Kym PR, Reilly RM, Zhao G, Mittelstadt SW, Cox BF. J Pharmacol Exp Ther. 2009 Aug;330(2):526-31.

In vivo efficacy of acyl CoA: diacylglycerol acyltransferase (DGAT) 1 inhibition - In vivo efficacy of acyl CoA: diacylglycerol acyltransferase (DGAT) 1 inhibition

King AJ, Segreti JA, Larson KJ, Souers AJ, Kym PR, Reilly RM, Collins CA, Voorbach MJ, Zhao G, Mittelstadt SW, Cox BF. Eur J Pharmacol. 2010 Jul 10;637(1-3):155-61.