A 939572

• Supplier: Tocris Bioscience
• Catalog: 3587
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1032229-3-6
• Chemical Name: 4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide
• Formula: C20H22ClN3O3
• Molecular Weight: 387.86
• Purity: >99 %
• Description: Potent stearoyl-CoA desaturase 1 (SCD1) inhibitor (IC 50 = 0.4 nM). Selective for SCD1 over a range of kinases and hERG channels. Inhibits proliferation of squamous cell carcinoma FaDu cells in vitro . Also induces cell death of undifferentiated human embryonic stem cells (ESCs). Orally bioavailable.

Product References

Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class - Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class

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Molecular and biochemical pharmacology of the histamine H4 receptor. - Molecular and biochemical pharmacology of the histamine H4 receptor.

Leurs R, Chazot PL, Shenton FC, Lim HD, de Esch IJ. Br J Pharmacol. 2009 May;157(1):14-23.

Histamine H4-receptors inhibit mast cell renin release in ischemia/reperfusion - Histamine H4-receptors inhibit mast cell renin release in ischemia/reperfusion

Aldi S, Takano K, Tomita K, Koda K, Chan NY, Marino A, Salazar-Rodriguez M, Thurmond RL, Levi R. J Pharmacol Exp Ther. 2014 Jun;349(3):508-17.