A 967079

• Supplier: Tocris Bioscience
• Catalog: 3753
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Blocker
• Cas Number: 1170613-55-4
• Chemical Name: (1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-oneoxime
• Formula: C12H14FNO
• Molecular Weight: 207.24
• Purity: >98 %
• Description: Selective TRPA1 channel blocker (IC 50 values are 67 and 289 nM at human and rat TRPA1 receptors respectively). Displays 1000-fold selectivity for TRPA1 over other TRP channels, and is >150-fold selective over 75 other ion channels, enzymes and G-protein-coupled receptors. Exhibits analgesic effects in a rat osteoarthritic pain model.

Product References

TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons - TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons

McGaraughty S, Chu KL, Perner RJ, Didomenico S, Kort ME, Kym PR. Mol Pain. 2010 Mar 5;6:14.

Selective blockade of TRPA1 channel attenuates pathological pain without altering - Selective blockade of TRPA1 channel attenuates pathological pain without altering

Chen J, Joshi SK, DiDomenico S, Perner RJ, Mikusa JP, Gauvin DM, Segreti JA, Han P, Zhang XF, Niforatos W, Bianchi BR, Baker SJ, Zhong C, Simler GH, McDonald HA, Schmidt RG, McGaraughty SP, Chu KL, Faltynek CR, Kort ME, Reilly RM, Kym PR. Pain. 2011 May;152(5):1165-72.