A 971432

• Supplier: Tocris Bioscience
• Catalog: 4716
• Prices: $135.00, $579.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 1240308-45-5
• Chemical Name: 1-[[4-[(3,4-Dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylicacid
• Formula: C18H17Cl2NO3
• Molecular Weight: 366.24
• Purity: >99 %
• Description: Potent and selective S1P 5 agonist (EC 50 values are 4.1 and 5.7 nM in cAMP and GTP γ S assays, respectively). Exhibits 60-fold selectivity over S1P 1 , and >1,600-fold selectivity over S1P 2-4 , and a panel of 129 kinases and 79 receptors. Improves blood-brain barrier integrity in vitro and reverses age-related cognitive decline in vivo . Orally available.

Product References

cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2 - cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2

Liu H, Altenbach RJ, Carr TL, Chandran P, Hsieh GC, Lewis LG, Manelli AM, Milicic I, Marsh KC, Miller TR, Strakhova MI, Vortherms TA, Wakefield BD, Wetter JM, Witte DG, Honore P, Esbenshade TA, Brioni JD, Cowart MD. J Med Chem. 2008 Nov 27;51(22):7094-8.

Molecular and biochemical pharmacology of the histamine H4 receptor. - Molecular and biochemical pharmacology of the histamine H4 receptor.

Leurs R, Chazot PL, Shenton FC, Lim HD, de Esch IJ. Br J Pharmacol. 2009 May;157(1):14-23.