| Name | A01 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3640 |
| Prices | $149.00, $629.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1007647-73-5 |
| Chemical Name | [4-[[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone |
| Formula | C22H20ClF3N4O3S |
| Molecular Weight | 512.93 |
| Purity | >98 % |
| Description | High affinity Smurf1 E3 ubiquitin ligase inhibitor (K d = 3.7 nM). Attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. Potentiates BMP-2-induced osteoblastic activity in C2C12 myoblasts and MC3T3-E1 osteoblast precursor cells. |
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