A12B4C3

• Supplier: Tocris Bioscience
• Catalog: 5397
• Prices: $235.00, $965.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1005129-80-5
• Chemical Name: 4a,7a-Dihydro-2-(1-hydroxyundecyl)-1-[(4-nitrophenyl)amino]-6-phenyl-1H-pyrrolo[3,4-b]pyridine-5,7(2H,6H)-dione
• Formula: C30H38N4O5
• Molecular Weight: 534.65
• Purity: >98 %
• Description: Potent and selective polynucleotide kinase/phosphatase (PNKP) inhibitor (IC 50 = 60 nM). Displays no effect on calcineurin, protein PP-1 or APTX. Interrupts DNA repair and enhances radiosensitivity of human A549 lung carcinoma and MDA-MB-231 cells.

Product References

Identification of a small molecule inhibitor of the human DNA repair enzyme - Identification of a small molecule inhibitor of the human DNA repair enzyme

Freschauf GK, Karimi-Busheri F, Ulaczyk-Lesanko A, Mereniuk TR, Ahrens A, Koshy JM, Rasouli-Nia A, Pasarj P, Holmes CF, Rininsland F, Hall DG, Weinfeld M. Cancer Res. 2009 Oct 1;69(19):7739-46.

Mechanism of action of an imidopiperidine inhibitor of human polynucleotide - Mechanism of action of an imidopiperidine inhibitor of human polynucleotide

Freschauf GK, Mani RS, Mereniuk TR, Fanta M, Virgen CA, Dianov GL, Grassot JM, Hall DG, Weinfeld M. J Biol Chem. 2010 Jan 22;285(4):2351-60.

DNA end processing by polynucleotide kinase/phosphatase. - DNA end processing by polynucleotide kinase/phosphatase.

Schellenberg MJ, Williams RS. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):20855-6. doi: