17-AAG

• Supplier: Tocris Bioscience
• Catalog: 1462
• Prices: $165.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 75747-14-7
• Chemical Name: 17-Demethoxy-17-(2-propenylamino)geldanamycin
• Formula: C31H43N3O8
• Molecular Weight: 585.7
• Purity: >98 %
• Description: Inhibitor of heat shock protein 90 (Hsp90) chaperone activity, and an analog of geldanamycin (Cat. No. 1368). Subsequently inhibits the activity of oncogenic proteins such as p185 erbB-2 (IC 50 = 31 nM), N-ras, Ki-ras and c-Akt. Antitumor in vivo . Also protects neuroprogenitor cells against stress-induced apoptosis at low concentrations (10 nM) in vitro .

Product References

Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by - Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by

Schnur RC, Corman ML, Gallaschun RJ, Cooper BA, Dee MF, Doty JL, Muzzi ML, Moyer JD, DiOrio CI, Barbacci EG, et al.. J Med Chem. 1995 Sep 15;38(19):3806-12.

Inhibition of signal transduction by the Hsp90 inhibitor - Inhibition of signal transduction by the Hsp90 inhibitor

Hostein I, Robertson D, DiStefano F, Workman P, Clarke PA. Cancer Res. 2001 May 15;61(10):4003-9.

Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to - Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to

Yang J, Yang JM, Iannone M, Shih WJ, Lin Y, Hait WN. Cancer Res. 2001 May 15;61(10):4010-6.

Protection of murine neural progenitor cells by the Hsp90 inhibitor - Protection of murine neural progenitor cells by the Hsp90 inhibitor

Wang G, Krishnamurthy K, Tangpisuthipongsa D. J Neurochem. 2011 May;117(4):703-11.