AAQ chloride

• Supplier: Tocris Bioscience
• Catalog: 1515
• Prices: $185.00, $755.00
• Sizes: 10 mg, 50 mg
• Function Type: Blocker
• Chemical Name: N,N,N-Triethyl-2-oxo-2-[[4-[2-[4-[(1-oxo-2-propen-1-yl)amino]phenyl]diazenyl]phenylamino]ethanaminiumchloride
• Formula: C23H30ClN5O2
• Molecular Weight: 443.97
• Purity: >98 %
• Description: Photoswitchable K v channel blocker (IC 50 values are 2 and 64 μ M at 500 nm and 380 nm respectively). Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Exhibits minimal activity at Na v 1.2 and L-type Ca 2+ channels. Stimulates action potential firing of hippocampal neurons in vitro at 500 nm and restores visual responsiveness in blind mice at 380 nm.

Product References

Photochemical control of endogenous ion channels and cellular excitability. - Photochemical control of endogenous ion channels and cellular excitability.

Fortin DL, Banghart MR, Dunn TW, Borges K, Wagenaar DA, Gaudry Q, Karakossian MH, Otis TS, Kristan WB, Trauner D, Kramer RH. Nat Methods. 2008 Apr;5(4):331-8.

Photochromic blockers of voltage-gated potassium channels. - Photochromic blockers of voltage-gated potassium channels.

Banghart MR, Mourot A, Fortin DL, Yao JZ, Kramer RH, Trauner D. Angew Chem Int Ed Engl. 2009;48(48):9097-101.

Photochemical restoration of visual responses in blind mice. - Photochemical restoration of visual responses in blind mice.

Polosukhina A, Litt J, Tochitsky I, Nemargut J, Sychev Y, De Kouchkovsky I, Huang T, Borges K, Trauner D, Van Gelder RN, Kramer RH. Neuron. 2012 Jul 26;75(2):271-82.