ABT 089 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 5038
• Prices: $179.00, $745.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 161416-61-1
• Chemical Name: 2-Methyl-3-[(2S)-pyrrolidinylmethoxy]pyridinedihydrochloride
• Formula: C11H16N2O.2HCl
• Molecular Weight: 265.18
• Purity: >98 %
• Description: High affinity and selective α 4 β 2 partial agonist (K i = 16 nM). Exhibits >1000-fold and >10,000-fold selectivity for α 4 β 2 over α 1 β 1 γ 1 and α 7 receptors respectively. Neuroprotective against glutamate-induced toxicity in rat cortical neurons in vitro . Enhances cognitive performance in vivo . Orally bioavailable and brain penetrant.

Product References

ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A - ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A

Decker MW, Bannon AW, Curzon P, Gunther KL, Brioni JD, Holladay MW, Lin NH, Li Y, Daanen JF, Buccafusco JJ, Prendergast MA, Jackson WJ, Arneric SP. J Pharmacol Exp Ther. 1997 Oct;283(1):247-58.

ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and - ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and

Sullivan JP, Donnelly-Roberts D, Briggs CA, Anderson DJ, Gopalakrishnan M, Xue IC, Piattoni-Kaplan M, Molinari E, Campbell JE, McKenna DG, Gunn DE, Lin NH, Ryther KB, He Y, Holladay MW, Wonnacott S, Williams M, Arneric SP. J Pharmacol Exp Ther. 1997 Oct;283(1):235-46.

ABT-089: pharmacological properties of a neuronal nicotinic acetylcholine - ABT-089: pharmacological properties of a neuronal nicotinic acetylcholine

Rueter LE, Anderson DJ, Briggs CA, Donnelly-Roberts DL, Gintant GA, Gopalakrishnan M, Lin NH, Osinski MA, Reinhart GA, Buckley MJ, Martin RL, McDermott JS, Preusser LC, Seifert TR, Su Z, Cox BF, Decker MW, Sullivan JP. CNS Drug Rev. 2004 Summer;10(2):167-82.