| Name | ABT 702 dihydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5079 |
| Prices | $259.00 |
| Sizes | 10 mg |
| Function Type | Inhibitor |
| Cas Number | 1188890-28-9 |
| Chemical Name | 5-(3-Bromophenyl)-7-[6-(4-morpholinyl)-3-pyrido[2,3-d]byrimidin-4-aminedihydrochloride |
| Formula | C22H19N6OBr.2HCl |
| Molecular Weight | 536.26 |
| Purity | >98 % |
| Description | Potent non-nucleoside adenosine kinase inhibitor (IC 50 = 1.7 nM), selective over other sites of adenosine interaction (A 1 , A 2A and A 3 receptors, adenosine transporter and adenosine deaminase). Displays oral activity in animal models of pain and inflammation. |
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Jarvis MF, Yu H, Kohlhaas K, Alexander K, Lee CH, Jiang M, Bhagwat SS, Williams M, Kowaluk EA. J Pharmacol Exp Ther. 2000 Dec;295(3):1156-64.
Kowaluk EA, Mikusa J, Wismer CT, Zhu CZ, Schweitzer E, Lynch JJ, Lee CH, Jiang M, Bhagwat SS, Gomtsyan A, McKie J, Cox BF, Polakowski J, Reinhart G, Williams M, Jarvis MF. J Pharmacol Exp Ther. 2000 Dec;295(3):1165-74.
Lee CH, Jiang M, Cowart M, Gfesser G, Perner R, Kim KH, Gu YG, Williams M, Jarvis MF, Kowaluk EA, Stewart AO, Bhagwat SS. J Med Chem. 2001 Jun 21;44(13):2133-8.