| Name | ABT 724 trihydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2372 |
| Prices | $155.00, $645.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Agonist |
| Cas Number | 587870-77-7 |
| Chemical Name | 2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazoletrihydrochloride |
| Formula | C17H19N5.3HCl |
| Molecular Weight | 402.75 |
| Purity | >99 % |
| Description | Potent dopamine D 4 receptor partial agonist (EC 50 = 12.4 nM; 61% efficacy vs. dopamine). Has no agonist activity at D 2 receptors (EC 50 > 10 μ M). Selective in rats in vivo ; produces penile erection following i.c.v. administration; increases intracavernosal pressure and potentiates the proerectile effects of sildenafil following s.c. administration. Displays minimal side effects. |
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Cowart M, Latshaw SP, Bhatia P, Daanen JF, Rohde J, Nelson SL, Patel M, Kolasa T, Nakane M, Uchic ME, Miller LN, Terranova MA, Chang R, Donnelly-Roberts DL, Namovic MT, Hollingsworth PR, Martino BR, Lynch JJ 3rd, Sullivan JP, Hsieh GC, Moreland RB, Brioni JD, Stewart AO. J Med Chem. 2004 Jul 15;47(15):3853-64.
Stewart AO, Cowart MD, Moreland RB, Latshaw SP, Matulenko MA, Bhatia PA, Wang X, Daanen JF, Nelson SL, Terranova MA, Namovic MT, Donnelly-Roberts DL, Miller LN, Nakane M, Sullivan JP, Brioni JD. J Med Chem. 2004 Apr 22;47(9):2348-55.