AC 186

Name AC 186
Supplier Tocris Bioscience
Catalog 4138
Prices $205.00, $845.00
Sizes 10 mg, 50 mg
Function Type Agonist
Cas Number 1421854-16-1
Chemical Name 4-[4,4-Difluoro-1-(2-fluorophenyl)cyclohexyl]phenol
Formula C18H17F3O
Molecular Weight 306.32
Purity >99 %
Description Potent and selective ER β agonist (EC 50 values are 6 and 5000 nM for ER β and ER α respectively). Exhibits gender selective neuroprotective effects in a male rat model of Parkinson's disease. Decreases A β levels in combination with ACP-105 in a rat model of Alzheimer's disease.
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Product References

Nonsteroidal selective androgen receptor modulators and selective estrogen - Nonsteroidal selective androgen receptor modulators and selective estrogen

George S, Petit GH, Gouras GK, Brundin P, Olsson R. ACS Chem Neurosci. 2013 Dec 18;4(12):1537-48.

AC-186, a selective nonsteroidal estrogen receptor beta agonist, shows gender - AC-186, a selective nonsteroidal estrogen receptor beta agonist, shows gender

McFarland K, Price DL, Davis CN, Ma JN, Bonhaus DW, Burstein ES, Olsson R. ACS Chem Neurosci. 2013 Sep 18;4(9):1249-55.