| Name | AC 187 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5053 |
| Prices | $299.00 |
| Sizes | 500 µg |
| Function Type | Antagonist |
| Cas Number | 151804-77-2 |
| Formula | C127H205N37O40 |
| Molecular Weight | 2890.25 |
| Description | Orally active, potent amylin receptor antagonist (IC 50 = 0.48 nM) that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. Blocks amyloid β -induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro . Increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo . |
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Gedulin BR, Jodka CM, Herrmann K, Young AA. Regul Pept. 2006 Dec 10;137(3):121-7. Epub 2006 Aug 17.