AC 264613

• Supplier: Tocris Bioscience
• Catalog: 4046
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 1051487-82-1
• Chemical Name: (±)-(3R*,4S*)-2-Oxo-4-phenyl-3-pyrollidinecarboxylicacid2-[1-(3-bromophenyl)ethylidene]hydrazide
• Formula: C19H18BrN3O2
• Molecular Weight: 400.27
• Purity: >98 %
• Description: Potent and selective protease-activated receptor 2 (PAR 2 ) agonist (pEC 50 = 7.5). Displays no activity at other PAR subtypes and exhibits no significant activity at over 30 other receptors implicated in nociception and inflammation. Stimulates PI hydrolysis, Ca 2+ mobilization and cellular proliferation in vitro (pEC 50 values are 6.9, 7.0 and 7.5 respectively).

Product References

Identification and characterization of novel small-molecule protease-activated - Identification and characterization of novel small-molecule protease-activated

Gardell LR, Ma JN, Seitzberg JG, Knapp AE, Schiffer HH, Tabatabaei A, Davis CN, Owens M, Clemons B, Wong KK, Lund B, Nash NR, Gao Y, Lameh J, Schmelzer K, Olsson R, Burstein ES. J Pharmacol Exp Ther. 2008 Dec;327(3):799-808.

Discovery of potent and selective small-molecule PAR-2 agonists. - Discovery of potent and selective small-molecule PAR-2 agonists.

Seitzberg JG, Knapp AE, Lund BW, Mandrup Bertozzi S, Currier EA, Ma JN, Sherbukhin V, Burstein ES, Olsson R. J Med Chem. 2008 Sep 25;51(18):5490-3.