| Name | AC 710 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2436 |
| Prices | $235.00, $965.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1351522-04-7 |
| Chemical Name | N-[4-[[[[5-(1,1-Dimethethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide |
| Formula | C31H42N6O4 |
| Molecular Weight | 562.7 |
| Purity | >99 % |
| Description | Potent PDGFR family inhibitor (IC 50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFR β and CSF1R respectively; K d = 1.3 nM for PDGFR α ). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active. |
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