cis -ACBD

• Supplier: Tocris Bioscience
• Catalog: 0258
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 73550-55-7
• Chemical Name: cis-1-Aminocyclobutane-1,3-dicarboxylicacid
• Formula: C6H9NO4
• Molecular Weight: 159.14
• Description: Potent, competitive and selective inhibitor of glutamate uptake. Certain confusion exists over the naming of this compound because of apparent contradictions in the literature. This is the isomer which has the carboxylic acid and the amino groups on the same side of the cyclobutyl ring.

Product References

Synthesis and activity of a potent N-methyl-D-aspartic acid agonist, - Synthesis and activity of a potent N-methyl-D-aspartic acid agonist,

Allan RD, Hanrahan JR, Hambley TW, Johnston GA, Mewett KN, Mitrovic AD. J Med Chem. 1990 Oct;33(10):2905-15.

Inhibition of high affinity L-glutamic acid uptake into rat cortical synaptosomes - Inhibition of high affinity L-glutamic acid uptake into rat cortical synaptosomes

Fletcher EJ, Mewett KN, Drew CA, Allan RD, Johnston GA. Neurosci Lett. 1991 Jan 2;121(1-2):133-5.

Differentiation of substrate and nonsubstrate inhibitors of the high-affinity, - Differentiation of substrate and nonsubstrate inhibitors of the high-affinity,

Koch HP, Kavanaugh MP, Esslinger CS, Zerangue N, Humphrey JM, Amara SG, Chamberlin AR, Bridges RJ. Mol Pharmacol. 1999 Dec;56(6):1095-104.