N -Acetyl-L-leucyl-L-leucyl-L-methional

Name N -Acetyl-L-leucyl-L-leucyl-L-methional
Supplier Tocris Bioscience
Catalog 0395
Prices $129.00, $535.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 136632-32-1
Formula C19H35N3O4S
Molecular Weight 401.56
Description Very potent inhibitor of cathepsin L (K i = 0.6 nM) and the strongest inhibitor of cathepsin B (K i = 100 nM) amongst the peptide aldehydes. Also inhibits processing of malaria aspartic hemoglobinases plasmepsins I and II in vitro .
Supplier Page Shop

Product References

Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins. - Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins.

Sasaki T, Kishi M, Saito M, Tanaka T, Higuchi N, Kominami E, Katunuma N, Murachi T. J Enzyme Inhib. 1990;3(3):195-201.

Biosynthesis and maturation of the malaria aspartic hemoglobinases plasmepsins I - Biosynthesis and maturation of the malaria aspartic hemoglobinases plasmepsins I

Francis SE, Banerjee R, Goldberg DE. J Biol Chem. 1997 Jun 6;272(23):14961-8.