Acifran

• Supplier: Tocris Bioscience
• Catalog: 4547
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Cas Number: 72420-38-3
• Chemical Name: 4,5-Dihydro-5-methyl-4-oxo-5-phenyl-2-furancarboxylicacid
• Formula: C12H10O4
• Molecular Weight: 218.21
• Purity: >99 %
• Description: Hypolipidemic agent. Exhibits higher potency than nicotinic acid and clofibrate. Full and potent agonist at the human orphan GPCR HM74A/GPR109A and GPR109B (EC 50 values are 1.3 and 4.2 μ M respectively). Reduces serum triglycerides and circulating LDL-cholesterol in vivo , without affecting liver weight or liver enzymes.

Product References

Evaluation of the lipid-lowering activity of AY-25,712 in rats. - Evaluation of the lipid-lowering activity of AY-25,712 in rats.

Cayen MN, Kallai-Sanfacon MA, Dubuc J, Greselin E, Dvornik D. Atherosclerosis. 1982 Dec;45(3):267-79.

Hypolipidemic 4,5-dihydro-4-oxo-5,5-disubstituted-2-furancarboxylic acids. - Hypolipidemic 4,5-dihydro-4-oxo-5,5-disubstituted-2-furancarboxylic acids.

Jirkovsky I, Cayen MN. J Med Chem. 1982 Oct;25(10):1154-6.

Molecular identification of high and low affinity receptors for nicotinic acid. - Molecular identification of high and low affinity receptors for nicotinic acid.

Wise A, Foord SM, Fraser NJ, Barnes AA, Elshourbagy N, Eilert M, Ignar DM, Murdock PR, Steplewski K, Green A, Brown AJ, Dowell SJ, Szekeres PG, Hassall DG, Marshall FH, Wilson S, Pike NB. J Biol Chem. 2003 Mar 14;278(11):9869-74. Epub 2003 Jan 9.

Analogues of acifran: agonists of the high and low affinity niacin receptors, - Analogues of acifran: agonists of the high and low affinity niacin receptors,

Jung JK, Johnson BR, Duong T, Decaire M, Uy J, Gharbaoui T, Boatman PD, Sage CR, Chen R, Richman JG, Connolly DT, Semple G. J Med Chem. 2007 Apr 5;50(7):1445-8. Epub 2007 Mar 15.