ACV 1

• Supplier: Tocris Bioscience
• Catalog: 1229
• Prices: $255.00
• Sizes: 100 µg
• Function Type: Antagonist
• Cas Number: 740980-24-9
• Formula: C71H103N23O25S4
• Molecular Weight: 1806.98
• Description: Neuronal nicotinic receptor antagonist that displays selectivity for the α 9 α 10 subtype (IC 50 values are 19, 140, 980, 4200 and 7300 nM for α 9 α 10, α 6/ α 3 β 2 β 3, α 6/ α 3 β 4, α 3 β 4 and α 3 β 2 subtypes respectively). Alleviates neuropathic pain in three rat models of human neuropathic pain and accelerates functional recovery of injured neurons.

Product References

A novel alpha-conotoxin identified by gene sequencing is active in suppressing - A novel alpha-conotoxin identified by gene sequencing is active in suppressing

Sandall DW, Satkunanathan N, Keays DA, Polidano MA, Liping X, Pham V, Down JG, Khalil Z, Livett BG, Gayler KR. Biochemistry. 2003 Jun 10;42(22):6904-11.

Are alpha9alpha10 nicotinic acetylcholine receptors a pain target for - Are alpha9alpha10 nicotinic acetylcholine receptors a pain target for

Nevin ST, Clark RJ, Klimis H, Christie MJ, Craik DJ, Adams DJ. Mol Pharmacol. 2007 Dec;72(6):1406-10. Epub 2007 Sep 5.

Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for - Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for

Halai R, Clark RJ, Nevin ST, Jensen JE, Adams DJ, Craik DJ. J Biol Chem. 2009 Jul 24;284(30):20275-84.