Adapalene

• Supplier: Tocris Bioscience
• Catalog: 2513
• Prices: $89.00, $355.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 106685-40-9
• Chemical Name: 6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylicacid
• Formula: C28H28O3
• Molecular Weight: 412.52
• Purity: >98 %
• Description: Retinoic acid analog that is a RAR β and RAR γ agonist (AC 50 values are 2.2, 9.3, 22 and > 1000 nM for RAR β , RAR γ , RAR α and RXR α receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cell in vitro . Displays comedolytic activity.

Product References

Pharmacology and chemistry of adapalene. - Pharmacology and chemistry of adapalene.

Shroot B, Michel S. J Am Acad Dermatol. 1997 Jun;36(6 Pt 2):S96-103.

Adapalene: an update on newer comparative studies between the various retinoids. - Adapalene: an update on newer comparative studies between the various retinoids.

Millikan LE. Int J Dermatol. 2000 Oct;39(10):784-8.

The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in - The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in

Ocker M, Herold C, Ganslmayer M, Hahn EG, Schuppan D. Int J Cancer. 2003 Nov 10;107(3):453-9.